After studying at the Conservatoire National Supérieur de Musique (Paris), she joined the Company of the Opéra National de Lyon where she sang Cherubino (Le Nozze di Figaro), Stefano (Roméo et Juliette), and Rosina (Il Barbiere di Siviglia).

She then started a long term collaboration with the Opéra National de Paris. She made her debut in Rusalka, and then took part in the productions of Juliette ou la Clé des Songes, Faust, and Veck Makropoulos. She also appeared at the Salzburg Festival as Second lady (Die Zauberflöte) with Riccardo Muti.

Very soon, she was invited by many French opera houses. She sang La Cenerentola at the Opéra National de Bordeaux, Zerlina (Don Giovanni) at the Théatre du Capitole, Toulouse and at the Opéra de Monte Carlo, Béatrice (Béatrice et Bénédict) at the Opéra National du Rhin. She made her debut at the Metropolitan Opera in the role of Siebel (Faust).She then sang  Nicklausse (Les Contes d'Hoffmann) at the Théâtre du Capitole in Toulouse, Adalgisa (Norma) at the Opéra de Saint-Etienne, Sesto (La Clemenza di Tito) at the Opéra d'Avignon, Poppea (L'Incoronazione di Poppea) at the Opera National de Bordeaux, Romeo (I Capuleti e i Montecchi) and Angelina (La Cenerentola) in Avignon, Charlotte (Werther) at the Opera de Lyon, Urbain (Les Huguenots) at the Teatro Real and at the Opéra National du Rhin, Siebel (Faust) at the Liceu of Barcelona, Rosina, Elena (La Donna del Lago), Cherubino (Le Nozze de Figaro), Dorabella (Cosi fan Tutte) and Angelina (La Cenerentola) at the Opera National de Paris.

More recently, she has sung the title role in La Navarraise at the Salle Pleyel, Carmen Sesto (Giulio Cesare), Charlotte (Werther), Romeo (I Capuleti e i Montecchi), Poppea (Incoronazione di Poppea) at the Opéra National de Paris, Fenena (Nabucco) at the Chorégies d’Orange, Isolier (Le Comte Ory) at the Metropolitan Opera and Rosina (Il Barbiere di Siviglia) at the Opéra d’Avignon.

Karine Deshayes also performs in concert and recital. Her performances include Les Nuits d’Eté at the Cité de la Musique, conducted by Emmanuel Krivine, and Ravel’s Sheherazadewith the Orchestra of the Liceu, conducted by Josep Pons. She was awarded with the Charles Cros prize for a “Fauré” recording in 2010, and named "Lyrical artist of the year" at the "Victoires de la Musique Classique" in 2011.

In 2014-2015 and beyond her engagements include Rosina (Il Barbiere di Siviglia) at the Opéra National de Paris, La Cenerentola at the San Francisco Opera, Nicklausse/La Muse (les Contes d’Hoffmann) at the Met with J.Levine, La belle Hélène in Toulon, re-invitations in Paris, Barcelona and at the Met,  her US Recital debut at the Kennedy Center, as well as many concerts.

Novaya Rossiya State Symphony Orchestra was founded in 1990 by decree of the Russian Government. In 2002, Yuri Bashmet became the orchestra's Artistic Director and Principal Conductor, opening a new page in the ensemble's history. 

The orchestra has collaborated with renowned conductors and soloists, including Valery Gergiev, Tan Dun, Alexander Lazarev, Teodor Currentzis, Vladimir Ashkenazy, Andres Mustonen, Maxim Vengerov, Jean-Luc Ponty, Barry Douglas, Peter Donohoe, Denis Matsuev, Elisabeth Leonskaja, Boris Berezovsky, Viktor Tretiakov, Gidon Kremer, Vadim Repin, Anne-Sophie Mutter and Sergey Krylov, Kristóf Baráti, Viktoria Mullova, Natalia Gutman, David Geringas, Alexander Knyazev, James Galway, Deborah Voigt, Anna Netrebko, Laura Kleikomb, Plácido Domingo, Montserrat Caballé, Anna Caterina Antonacci, Patricia Cioffi, Elīna Garanča and ballet dancers Ulyana Lopatkina, Nikolai Tsiskaridze and Ilze Liepa as well as actors Konstantin Khabensky and Sergei Bezrukov.

Since 2002, the orchestra has given over 1000 concerts in Russia and abroad. Russian performances have taken place in Moscow and St. Petersburg, cities and towns of the Volga region and the Golden Ring, of the Urals and Siberia, while international tours have brought the musicians to countries like Austria, France, Germany, Italy, Japan, Netherlands, Poland, Republic of Korea, Spain, Switzerland, UK, Baltic and Nordic countries, and many others. 

The orchestra's repertoire combines classical and contemporary music of various styles and genres. It has premiered works by Gian Carlo Menotti, Edison Denisov, Mikael Tariverdiev, Sofia Gubaidulina, Giya Kancheli, Alexander Tchaikovsky, Tan Dun, Jean-Luc Ponty, Toru Takemitsu, Igor Raichelson, Emil Tabakov, Alexander Baltin, Vladimir Komarov, Boris Frankstein, Georgy Buzogly, Kuzma Bodrov and Alexey Sumak. 

The orchestra regularly appears at Yuri Bashmet's Winter International Arts Festival in Sochi and at international festivals in Yaroslavl, Rostov-on-Don and Minsk. It has taken part in the Mstislav Rostropovich Festival, Moscow Easter Festival, Guitar Virtuosi and Vivacello Festivals. The orchestra's discography includes works by Mozart, Beethoven, Weber, Brahms, Tchaikovsky, Rachmaninov, and Alexander Tchaikovsky. 

In March 2007, the orchestra received a grant from the Government of the Russian Federation, followed by the Grant of the President of the Russian Federation in 2010. In 2014, Novaya Rossiya was involved in preparing and running the cultural programme of the 22th Winter Olympic Games in Sochi. 

In the 2021/22 season, the orchestra presents subscription concert cycles at the Tchaikovsky Concert Hall and the Rachmaninov Concert Hall (Philharmonia-2) in Moscow, some of which will focus on young audiences. Conductors Alexander Sladkovsky, Igor Razumovsky, Denis Vlasenko and soloists Alena Baeva, Gaik Kazazian, Viviane Hagner, Zlatomir Fang, Boris Berezovsky, Dmitry Masleyev, Olga Seliverstova, Yaroslav Abaimov and many others will appear alongside the orchestra throughout the season.

«To “Masters of Choral Singing”: You are real Masters and it is pleasure to work with a chorus of such quality!» — Christoph Eschenbach, conductor.

Grand choir was founded in 1928, its founder and first artistic director was a master of choral art A.V.Sveshnikov. At various times, he was guided by such great musicians as N.S.Golovanov, I.M.Kuvykin, K.B.Ptitsa, L.V.Ermakova.

In 2005, the Grand Choir (known as the «Masters of Choral Singing») for the post of artistic director was invited by the People’s Artist of Russia, Professor Lev Kontorovich. Under his leadership, the updated composition of the choir successfully continues the traditions established by their predecessors. The name itself — «Masters of Choral Singing» — determined the professionalism, high level of performance, exceptional speed and versatility of the team, where each artist can act as a member of the choir and as a soloist.

For 85 years, the choir performed more than 5,000 works — operas, oratorios, cantatas Russian and foreign composers, works a’cappella, folk songs and sacred music. Many of them were the «golden fund» of the national record, gained recognition abroad (Grand Prix competition of recordings in Paris, the «Gold Medal» in Valencia). In the performance of a large choir were first heard many choral works by Prokofiev, Shostakovich, Shchedrin, Aram Khachaturian, O.Taktakishvili, V.Agafonnikova, Yu.Evgrafova etc.

With a large choir at various times such outstanding conductors as E.Svetlanov, M.Rostropovich, V.Spivakov, D.Kitaenko, V.Fedoseev, H.Rilling, G.Rozhdestvensky, A.Dzedda, E.Morrikone, V.Jurowski, M.Pletnev, K.Eshenbah; singers E. Obraztsova, I.Arkhipov, N.Gedda, D.Hvorostovsky, A.Netrebko, Z.Sotkilava, E.Nesterenko, R.Alanya, A.Georgiu, V.Ladyuk and many others.

In 2008 and 2012 the Grand choir took part in the inauguration ceremony of President of the Russian Federation Dmitry Medvedev and Vladimir Putin.

Grand choir clapped their hands in the major concert halls of Russia, Italy, France, Germany, Israel, Bulgaria, Czechoslovakia, Japan, South Korea, Qatar, Indonesia and others held touring Grand choir for major cities of the Urals and Siberia (Dmitri Hvorostovsky) and the Far East.